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PHENOXYETHANOL

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PHENOXYETHANOL

image source: PubChem

Health Concerns of the Ingredient:
Overall Hazard
Cancer 
Developmental & reproductive toxicity
 
Allergies & immunotoxicity
 
Use restrictions
 

About PHENOXYETHANOL: Phenoxyethanol is a preservative used in cosmetics and personal care products.

Function(s): Fragrance Ingredient; Preservative

Synonym(s): 2-HYDROXYETHYL PHENYL ETHER; 2-PHENOXY- ETHANOL; 2-PHENOXYETHANOL; 2-PHENOXYETHYL ALCOHOL; ETHANOL, 2-PHENOXY-; ETHANOL, 2PHENOXY; ETHYLENE GLYCOL MONOPHENYL ETHER; PHENOXYTOL; 1-HYDROXY-2-PHENOXYETHANE; 2-FENOXYETHANOL (CZECH) ; 2-PHENOXYETHANOL

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit) Japan's Standards for Cosmetics

Allergies/immunotoxicity

Concern Reference
Limited evidence of skin and immune system toxicity or allergies Heidary N, Cohen DE

Organ system toxicity (non-reproductive)

Concern Reference
Limited evidence of nervous toxicity National Library of Medicine, HazMap database
Classified as toxic or harmful (only for products for use around the mouth; products for use on the lips) European Union - Classification & Labelling
Classified as not expected to be potentially toxic or harmful Environment Canada Domestic Substance List
Classified as a low human health priority Environment Canada Domestic Substance List

Occupational hazards

Concern Reference
Allowed workplace exposures restricted to low doses European Union - Classification & Labelling

 

Irritation (skin, eyes, or lungs)

Concern Reference
Classified as irritant European Union - Classification & Labelling

 

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product Cosmetic Ingredient Review Assessments
277 studies in PubMed science library may include information on the toxicity of this chemical see search results -> NLM PubMed

 Ecotoxicology

Concern Reference
Not suspected to be an environmental toxin Environment Canada Domestic Substance List

 Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Heidary N, Cohen DE. Hypersensitivity reactions to vaccine components. Dermatitis. 2005 Sep;16(3):115-20.
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

National Library of Medicine, HazMap database. http://hazmap.nlm.nih.gov/category-details?id=1901

Reference :http://www.ewg.org/skindeep/ingredient/704811/PHENOXYETHANOL/

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